{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:50:33Z","timestamp":1791589833533,"version":"4.3.4"},"reference-count":325,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of intestinal diseases such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short bowel syndrome (SBS), and irritable bowel syndrome (IBS). While FMT has shown high efficacy in the treatment of rCDI, further research is needed for its application in other chronic conditions. This article elaborates on the application of FMT in intestinal diseases and the mechanisms of intestinal dysbiosis, as well as discusses key factors influencing the effectiveness of FMT, including donor selection, recipient characteristics, treatment protocols, and methods for assessing microbiota. Additionally, it emphasizes the key to successful FMT. Future research should focus on optimizing the FMT process to ensure long\u2010term safety and explore the potential application of FMT in a broader range of medical conditions.<\/jats:p>","DOI":"10.1002\/advs.202413197","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:44:09Z","timestamp":1741697049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Advances in Fecal Microbiota Transplantation for Gut Dysbiosis\u2010Related Diseases"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2177-3209","authenticated-orcid":false,"given":"Shuna","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"},{"name":"Department of general surgery The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of general surgery The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-4148","authenticated-orcid":false,"given":"Zhiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Fourth Affiliated Hospital of China Medical University China Medical University  Liao Ning Shen Yang 110032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8787"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10080988"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.26050"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400731"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2021.01.010"},{"key":"e_1_2_8_7_1","first-page":"24","volume":"11","author":"Lee W. J.","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12567"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25973"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12087"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000750"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.08.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0636-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.251"},{"key":"e_1_2_8_16_1","volume-title":"Merde, Excursions Into Scientific, Cultural, and Socio\u2010Historical Coprology","author":"Marschall L. A.","year":"1999"},{"key":"e_1_2_8_17_1","first-page":"854","volume":"44","author":"Eiseman B.","year":"1958","journal-title":"Surgery"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100642"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318292fa0d"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx063"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002339"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133925"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13290"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130848"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.06.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06185-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914500"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31973-2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37172"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702156114"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.04.019"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1098386"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01546"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12365"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5096"},{"key":"e_1_2_8_38_1","first-page":"448 e8","volume":"153","author":"Pinto\u2010Sanchez M. I.","year":"2017","journal-title":"Gastroenterology"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9040836"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i21.2834"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00767-0"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-217576"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1237164"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1993584"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003053"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2019.04.001"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01115-9"},{"key":"e_1_2_8_48_1","first-page":"231","volume":"31","author":"Bichkaeva F. A.","year":"2018","journal-title":"Adv. Gerontol."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.007"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0350-x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01486"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.03.071"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490981"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001948"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00316.2020"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1023806"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2018.05.001"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5632"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32457-z"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16040529"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.02.018"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108273"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08530"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4466"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200303000-00005"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200409000-00009"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.007"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301403200"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72151"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0492-6"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02482-2"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-081022-021207"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0860-5"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.10.003"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100542"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1442-6"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.06.008"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081570"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.11.015"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102601"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31949-0"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R500013-JLR200"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13333"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.829525"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.06.002"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.761836"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01101-1"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.119"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0510-8"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.003"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228932"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-8006-6"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01581"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2019.1674124"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093143"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008201"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.21216"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.5.1979-1986.2006"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06208-3"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2012.12.020"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60821-w"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010015"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031397"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1810531"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01765-07"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00610-10"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804437105"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13828"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00191"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2018.04.001"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00282.2013"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2018.1455790"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00570-22"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144119"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03539-6"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01242"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181c87e02"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.482"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1803103"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.020"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1238-8"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00465-1"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1221789"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.88"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1603758"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.01.009"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051234"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2002.02044"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108415"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1217165"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.006"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1973356"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10835-8"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03152-2"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820968423"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607116658762"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2377"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.049"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2876"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1447380"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.05.004"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.003"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S268943"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010032"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14298"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1126808"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606932"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8050677"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa408"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092211"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2024.105373"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2149214"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.09.038"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090335"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100420"},{"key":"e_1_2_8_161_1","volume":"4","author":"Minkoff N. Z.","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.008"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00338-12"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12503"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913554107"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.03.010"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1086\/525047"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245822"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07359-8"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13847"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0651-8174"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.01.002"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.012"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14050507"},{"key":"e_1_2_8_175_1","first-page":"1","volume":"53","author":"Tamboli C. P.","year":"2004","journal-title":"Dysbiosis Inflammatory Bowel Disease Gut"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.001"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.5"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00048-4"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13410"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14387"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136947"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200307000-00012"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05220.x"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.001"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-0792-5"},{"key":"e_1_2_8_186_1","first-page":"476","volume":"9","author":"Bethlehem L.","year":"2024","journal-title":"Microbiota Therapeutics Inflammatory Bowel Disease, Way Forward Lancet Gastroenterol Hepatol."},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2023.00085"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-02924-x"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111851"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2019.03.006"},{"key":"e_1_2_8_191_1","first-page":"543","volume":"114","author":"Cheng F.","year":"2022","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"e_1_2_8_192_1","first-page":"453","volume":"11","author":"Dai L. N.","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00019"},{"key":"e_1_2_8_194_1","first-page":"159","volume":"62","author":"Simren M.","year":"2013","journal-title":"Intestinal Microbiota Funct. Bowel Disorders, Rome Foundat. Report Gut"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.655258"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.935830"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gox036"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000472"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02929-7"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2016.06.005"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.11.013"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1541736"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-020-02207-z"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.02.053"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.08.004"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028004210"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900603"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12784"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115619931"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1023441"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2023.02.011"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31548-8"},{"key":"e_1_2_8_213_1","first-page":"1","volume":"48","author":"Kilincarslan S.","year":"2020","journal-title":"Actas. Esp. Psiquiatr."},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000530"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0954"},{"key":"e_1_2_8_217_1","first-page":"566","volume":"34","author":"Tack J.","year":"2016","journal-title":"Modern Management of Irritable Bowel Syndrome, More Than Motility Dig Dis"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.04.003"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.1.19"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000523"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0729-1"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1955543"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1218585"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.01.142"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5086-4"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6961783"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00346"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1952365"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.813204"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.002"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.008"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i13.1341"},{"key":"e_1_2_8_233_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.613120"},{"key":"e_1_2_8_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41538-024-00253-2"},{"key":"e_1_2_8_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108682"},{"key":"e_1_2_8_236_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0222-5"},{"key":"e_1_2_8_237_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471919"},{"key":"e_1_2_8_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30338-2"},{"key":"e_1_2_8_239_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1794263"},{"key":"e_1_2_8_240_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194904"},{"key":"e_1_2_8_241_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1624815"},{"key":"e_1_2_8_242_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15740"},{"key":"e_1_2_8_243_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319630"},{"key":"e_1_2_8_244_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13983"},{"key":"e_1_2_8_245_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i18.2219"},{"key":"e_1_2_8_246_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.013"},{"key":"e_1_2_8_247_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316434"},{"key":"e_1_2_8_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30198-0"},{"key":"e_1_2_8_249_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00596-9"},{"key":"e_1_2_8_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01779-2"},{"key":"e_1_2_8_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2017.06.002"},{"key":"e_1_2_8_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.615056"},{"key":"e_1_2_8_253_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10010026"},{"key":"e_1_2_8_254_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318556"},{"key":"e_1_2_8_255_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09054-2"},{"key":"e_1_2_8_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30952-5"},{"key":"e_1_2_8_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3610"},{"key":"e_1_2_8_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2019.05.001"},{"key":"e_1_2_8_259_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7528"},{"key":"e_1_2_8_260_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309800"},{"key":"e_1_2_8_261_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.465"},{"key":"e_1_2_8_262_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001842"},{"key":"e_1_2_8_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.07.012"},{"key":"e_1_2_8_264_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.020"},{"key":"e_1_2_8_265_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001261107"},{"key":"e_1_2_8_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106101"},{"key":"e_1_2_8_267_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33178-z"},{"key":"e_1_2_8_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0129-6"},{"key":"e_1_2_8_269_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2367"},{"key":"e_1_2_8_270_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0701"},{"key":"e_1_2_8_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.01.019"},{"key":"e_1_2_8_272_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah3648"},{"key":"e_1_2_8_273_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400286"},{"key":"e_1_2_8_274_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21491"},{"key":"e_1_2_8_275_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020386"},{"key":"e_1_2_8_276_1","first-page":"102315","volume-title":"Fecal Microbiota Transplantation Plus Tislelizumab and Fruquintinib in Refractory Microsatellite Stable Metastatic Colorectal Cancer, an Open\u2010Label, Single\u2010Arm, Phase II trial (RENMIN\u2010215)","author":"Zhao W.","year":"2023"},{"key":"e_1_2_8_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlife.2024.01.006"},{"key":"e_1_2_8_278_1","first-page":"757","volume":"25","author":"Society of, P., C.M.A. Enteral Nutrition, and A. Microecology Professional Committee of Shanghai Preventive Medicine, (2022 edition)]","year":"2022","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"e_1_2_8_279_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.038"},{"key":"e_1_2_8_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00007-8"},{"key":"e_1_2_8_281_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0222-x"},{"key":"e_1_2_8_282_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.50"},{"key":"e_1_2_8_283_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0337-1"},{"key":"e_1_2_8_284_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618780762"},{"key":"e_1_2_8_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104088"},{"key":"e_1_2_8_286_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb5920"},{"key":"e_1_2_8_287_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-313952"},{"key":"e_1_2_8_288_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-021-00512-4"},{"key":"e_1_2_8_289_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01695-5"},{"key":"e_1_2_8_290_1","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02159-21","volume":"11","author":"Zhang B.","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"e_1_2_8_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.053"},{"key":"e_1_2_8_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3695"},{"key":"e_1_2_8_293_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0257-y"},{"key":"e_1_2_8_294_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0395-5"},{"key":"e_1_2_8_295_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.045"},{"key":"e_1_2_8_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01553-7"},{"key":"e_1_2_8_297_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312297"},{"key":"e_1_2_8_298_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01964-3"},{"key":"e_1_2_8_299_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071399"},{"key":"e_1_2_8_300_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231174298"},{"key":"e_1_2_8_301_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000581"},{"key":"e_1_2_8_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00400-3"},{"key":"e_1_2_8_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.01.018"},{"key":"e_1_2_8_304_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327811"},{"key":"e_1_2_8_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30182-4"},{"key":"e_1_2_8_306_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01399-2"},{"key":"e_1_2_8_307_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088"},{"key":"e_1_2_8_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100711"},{"key":"e_1_2_8_309_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01913-0"},{"key":"e_1_2_8_310_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv203"},{"key":"e_1_2_8_311_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155214"},{"key":"e_1_2_8_312_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4183880"},{"key":"e_1_2_8_313_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.759306"},{"key":"e_1_2_8_314_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2223330"},{"key":"e_1_2_8_315_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000661"},{"key":"e_1_2_8_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.10.029"},{"key":"e_1_2_8_317_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01673-4"},{"key":"e_1_2_8_318_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.923599"},{"key":"e_1_2_8_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.013"},{"key":"e_1_2_8_320_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i38.6983"},{"key":"e_1_2_8_321_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910437"},{"key":"e_1_2_8_322_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.010"},{"key":"e_1_2_8_323_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0598-x"},{"key":"e_1_2_8_324_1","doi-asserted-by":"publisher","DOI":"10.1038\/4441022a"},{"key":"e_1_2_8_325_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-019-9832-9"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202413197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:44:27Z","timestamp":1759783467000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202413197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":325,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/advs.202413197"],"URL":"https:\/\/doi.org\/10.1002\/advs.202413197","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2413197"}}