{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:57:18Z","timestamp":1788926238369,"version":"build-2803163510"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, and exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, and enzyme\u2010inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for nanoengineering phosphate\/phosphonate drugs is introduced. By leveraging the difference in coordination capabilities between polyphenols and phosphates\/phosphonates with metal ions, various phosphate\/phosphonate\u2010based nanodrugs using metal\u2010phenolic networks (MPNs) as templates and phosphate\/phosphonate drugs as competitive agents are constructed. The dynamic nature of these coordination bonds imparts stimuli\u2010responsiveness to the nanodrugs, allowing for targeted release and therapy. As a proof of concept, Fe<jats:sup>3+<\/jats:sup> and galangin are used to form the MPN template, zoledronic acid and cGAMP as competitive agents, and DOX as the loaded drug to construct DOX@Fe\u2010galangin@Fe\u2010zoledronic acid\u2010cGAMP nanodrugs. The results demonstrate that, by triggering pyroptosis and activating the cGAS\u2010STING pathway, the nanodrugs exhibit potent cytotoxicity and accurate selectivity in eradicating orthotopic breast tumors, and activate an antitumor immune response against lung and bone metastases. Because the competitive coordination strategy is applicable to a variety of phosphate\/phosphonate agents, it holds significant potential for enhancing the clinical efficacy of phosphate\/phosphonate drugs and advancing nanodrug development for complex therapeutic applications.<\/jats:p>","DOI":"10.1002\/advs.202413201","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T08:04:06Z","timestamp":1731917046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nanoengineering of Phosphate\/Phosphonate Drugs via Competitive Replacement with Metal\u2010Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis"],"prefix":"10.1002","volume":"12","author":[{"given":"Wanrui","family":"Shi","sequence":"first","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry Institute of Translational Medicine The First Hospital of Jilin University  Changchun 130021 P. R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Feng","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry Institute of Translational Medicine The First Hospital of Jilin University  Changchun 130021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Centre The First Hospital of Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University  Shanghai 200438 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry Institute of Translational Medicine The First Hospital of Jilin University  Changchun 130021 P. R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-1100","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Joint Laboratory of Opto\u2010Functional Theranostics in Medicine and Chemistry Institute of Translational Medicine The First Hospital of Jilin University  Changchun 130021 P. R. China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0120-1"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.138"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155590"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3072"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/nature18268"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00962-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1877"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10347"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0263-0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60250-6"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.107"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113100"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.166"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00464-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00048-6"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2003.07.001"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305151"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01490"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201407130"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja031818y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936020-00004"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/009127002762491316"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.11.2401"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01122"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02916"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03828"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01251-z"},{"key":"e_1_2_8_12_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01134-z"},{"key":"e_1_2_8_12_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01225-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.073"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901430"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.092"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2608"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.01.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04299"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.10.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0177-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202312925"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013406"},{"key":"e_1_2_8_20_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302448"},{"key":"e_1_2_8_20_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202208037"},{"key":"e_1_2_8_20_5","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230117"},{"key":"e_1_2_8_20_6","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00343G"},{"key":"e_1_2_8_20_7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00172"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201601193"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902650"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05229"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201601147"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012699"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joule.2018.09.019"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804792"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201800817"},{"key":"e_1_2_8_25_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja507971r"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn0960"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101926"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00672C"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00217F"},{"key":"e_1_2_8_28_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c06679"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c09406"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.6b00537"},{"key":"e_1_2_8_29_3","doi-asserted-by":"publisher","DOI":"10.1021\/bm5017139"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00825-x"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04543"},{"key":"e_1_2_8_30_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09919"},{"key":"e_1_2_8_30_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11652"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2071-9"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14128"},{"key":"e_1_2_8_31_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2079-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0090-y"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704877"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc749"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101840"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3921"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3558"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105301"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.03.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-177"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202413201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:13:47Z","timestamp":1759756427000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202413201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/advs.202413201"],"URL":"https:\/\/doi.org\/10.1002\/advs.202413201","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2413201"}}