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Various radiation\u2010induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO\n                    <jats:sub>x<\/jats:sub>\n                    (Fe\u2010VO\n                    <jats:sub>x<\/jats:sub>\n                    ) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging. Fe doping can induce structure reconstruction of nanozymes with abundant defect production, including Fe substitution and oxygen vacancies (OVs), which markedly increased multiple enzyme\u2010mimicking activity. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme\u2010like performance of Fe\u2010VO\n                    <jats:sub>x<\/jats:sub>\n                    can effectively reprogram jawbone microenvironment to restore mitochondrial dysfunction and enhance mitophagy. Moreover, the surface plasmon resonance (SPR) effect of Fe\u2010VO\n                    <jats:sub>x<\/jats:sub>\n                    made it a good photothermal nanoagents for inhibiting jaw infection. Thus, this work demonstrated that Fe\u2010VO\n                    <jats:sub>x<\/jats:sub>\n                    nanozymes can efficiently scavenge RONS, activate mitophagy, and inhibit bacteria, which is potential for ORNJ treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202413215","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:11:36Z","timestamp":1734405096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Zheng","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral 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