{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:59:42Z","timestamp":1793134782696,"version":"4.5.0"},"reference-count":173,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007404","name":"Clinical Trial Center, China Medical University Hospital","doi-asserted-by":"publisher","award":["22585401"],"award-info":[{"award-number":["22585401"]}],"id":[{"id":"10.13039\/100007404","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates and poor patient prognosis. The heterogeneity and complex biology of GBM, coupled with the protective nature of the blood\u2013brain barrier (BBB), significantly limit the efficacy of traditional therapies. The rapid development of nanoenzyme technology presents a promising therapeutic paradigm for the rational and targeted treatment of GBM. In this review, the underlying mechanisms of GBM pathogenesis are comprehensively discussed, emphasizing the impact of the BBB on treatment strategies. Recent advances in nanoenzyme\u2010based approaches for GBM therapy are explored, highlighting how these nanoenzymes enhance various treatment modalities through their multifunctional capabilities and potential for precise drug delivery. Finally, the challenges and therapeutic prospects of translating nanoenzymes from laboratory research to clinical application, including issues of stability, targeting efficiency, safety, and regulatory hurdles are critically analyzed. By providing a thorough understanding of both the opportunities and obstacles associated with nanoenzyme\u2010based therapies, future research directions are aimed to be informed and contribute to the development of more effective treatments for GBM.<\/jats:p>","DOI":"10.1002\/advs.202413367","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:06:36Z","timestamp":1737695196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment"],"prefix":"10.1002","volume":"12","author":[{"given":"Liyin","family":"Wang","sequence":"first","affiliation":[{"name":"Shengjing Hospital of China Medical University  Liaoning 110004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University  Liaoning 110004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University  Liaoning 110004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Kong","sequence":"additional","affiliation":[{"name":"Shenyang Sport University  Liaoning 110102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-2685","authenticated-orcid":false,"given":"Jun","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Systems Biomedicine Beijing Key Laboratory of Tumor Systems Biology School of Basic Medical Sciences Peking University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University  Liaoning 110004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwu","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University  Liaoning 110001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0025-8"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0003-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21613"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014944"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.01.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101896"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00621-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0258-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.09.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0433-y"},{"key":"e_1_2_10_12_1","first-page":"91","volume":"33","author":"Lukas R. V.","year":"2019","journal-title":"Oncology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.081"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116392"},{"key":"e_1_2_10_15_1","author":"Sweeney M. D.","year":"2018","journal-title":"Physiol. Rev."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0205-x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00139-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402445"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01481-w"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30293-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.043"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912012117"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.007"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.02.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01536-y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122852"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.02.039"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0567-y"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00496-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11125"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05427E"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202108650"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007247"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1808"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-0530-4"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21765"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01141-9"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.005"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.043"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114614"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100970"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402376"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114449"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.025"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00383"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8090634"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00918D"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh097"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S146111"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1660970"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00140"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129431"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214170"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.05.022"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.06.032"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900192"},{"key":"e_1_2_10_63_1","first-page":"423","volume-title":"Endoscopic Laser Surgery Handbook","author":"Dougherty T. J.","year":"2020"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900132"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119827"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100946"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210415"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104223"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-021-00717-0"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB00451A"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-022-00828-2"},{"key":"e_1_2_10_72_1","volume":"12","author":"Grech N.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.12.039"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-9035-6_33"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01892-8"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1511"},{"key":"e_1_2_10_77_1","first-page":"719","volume":"29","author":"Weathers S.\u2010P.","year":"2015","journal-title":"Oncology"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5391"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110683"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00860-7"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S140462"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0318-2"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2545"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-023-09876-7"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S186142"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.06.017"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41692"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.01.009"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.03.011"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2612-2"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00544-0"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798772"},{"key":"e_1_2_10_93_1","first-page":"17","volume":"4","author":"Singh N.","year":"2021","journal-title":"Cancer Drug Resist."},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14250"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.04.022"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.08.004"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.053"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3874"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1375"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103790"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0568-z"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00188"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09853-z"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1474"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab269"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807105115"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.02.002"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.072"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201900259"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-019-00679-2"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03785"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.026"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.11.059"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03556-y"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab302"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000520"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.07.015"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6102"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.05.002"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2731-2"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906346116"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00748"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.03.009"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01701-5"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.01.069"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12968"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.008"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203958"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1766"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801391"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.11.031"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6564585"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000198"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801362"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2247-3"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01511-z"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox175"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020528"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.015"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119491"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9342796"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_302_17"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.020"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30322-X"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0175-0"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1637"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.06.009"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-024-00205-1"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215519"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00924-1"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08008"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S129300"},{"key":"e_1_2_10_155_1","volume":"18","author":"Han X.","year":"2024","journal-title":"ACS Nano"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101530"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204937"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.025"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00999"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-022-03738-9"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc8733"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003563"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00603"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117155"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb12040053"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904056"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3495"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03696"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35709-0"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312197"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405937"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1609"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13993-7"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202413367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:24:59Z","timestamp":1759757099000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202413367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":173,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/advs.202413367"],"URL":"https:\/\/doi.org\/10.1002\/advs.202413367","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2413367"}}