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Delivering dynamic mechanical forces to neural cells proves challenging due to the skull. Inspired by the effects of massage; here PEGylated black phosphorus nanosheets (PEG\u2010BPNS), known for their excellent biocompatibility, biodegradability, specific surface area, mechanical strength, and flexibility, are introduced, which are capable of adhering to neural cell membrane and generating mechanical stimulation with their lateral size of 200\u00a0nm, exhibiting therapeutic potential in a 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010te\u2010trahydropyridine\u2010induced PD mouse model by regulating inter\u2010organelle contacts. Specifically, it is found that 200\u00a0nm PEG\u2010BPNS, acting as \u201cNanoMassage,\u201d significantly increase \u00a0plasma membrane tension, as evidenced by fluorescent lipid tension reporter fluorescence lifetime analysis. This mechanical force modulates actin reorganization, subsequently regulating the contacts between actin, mitochondria, and endoplasmic reticulum, further controlling mitochondrial fission and mitigating mitochondrial dysfunction in PD, exhibiting therapeutic efficacy via intranasal administration. These findings provide a noninvasive strategy for applying mechanical stimulation to deep brain areas and elucidate the mechanism of NanoMassage mediating inter\u2010organelle contacts, suggesting the rational design of \u201cNanoMassage\u201d to remodel inter\u2010organelle communications in neurodegenerative disease treatment.<\/jats:p>","DOI":"10.1002\/advs.202413376","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T02:39:57Z","timestamp":1744598397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Massage\u2010Mimicking Nanosheets Mechanically Reorganize Inter\u2010organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Tianqi","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University  Tianjin 300350 P. R. 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