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Although recent evidence indicates that the peripheral nervous system is associated with tumor progression, its role in EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL remains poorly understood. In the cohort, patients with EBV\u207aDLBCL exhibit significantly shorter overall survival (OS). Two EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL cell lines are established and characterized. Although cell proliferation does not differ significantly in vitro, tumors derived from EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL cells demonstrate accelerated growth compared to their parental counterparts in mouse models. Mechanistically, transcriptome analysis reveals the upregulation of axonogenesis\u2010related genes and pathways in EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL tumors. Immunostaining confirms increased nerve fiber infiltration in SUDHL6\u2010EBV xenografts and enhance neurite outgrowth from dorsal root ganglia co\u2010cultured with EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL cells. Both in vitro and in vivo experiments show that sympathetic nerves promote tumor growth via \u03b22\u2010adrenergic receptors (\u03b22ARs), which are attenuated by selective \u03b22AR blockers. Clinically, EBV\u207aDLBCL patient samples show more sympathetic nerve fibers and higher \u03b22AR expression, both of which are associated with poorer survival. Furthermore, a meta\u2010analysis suggests that beta\u2010blocker use is linked to a reduced risk of cancer\u2010specific mortality. Together, these findings suggest that sympathetic nerve innervation drives the progression of EBV\n                    <jats:sup>+<\/jats:sup>\n                    DLBCL via \u03b22ARs, highlighting a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/advs.202413580","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:08:22Z","timestamp":1749726502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tumor\u2010Associated Sympathetic Nerves Promote the Progression of Epstein\u2010Barr Virus\u2010Positive Diffuse Large B\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Silan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou 510060 P. 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