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Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have been renewed as fascinating treatment options and have gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions of psychiatric disorders resulting from individuality, complex genetic interplay, and intricate neural circuits impact the systemic pharmacology of psychedelics, which disturbs the integration of mechanisms that may result in dissimilar medicinal efficiency. The precise prescription of psychedelic drugs remains unclear, and advanced approaches are needed to optimize drug development. Here, recent studies demonstrating the diverse pharmacological effects of psychedelics in mental disorders are reviewed, and emerging perspectives on structural function, the microbiota\u2010gut\u2010brain axis, and the transcriptome are discussed. Moreover, the applicability of deep learning is highlighted for the development of drugs on the basis of big data. These approaches may provide insight into pharmacological mechanisms and interindividual factors to enhance drug discovery and development for advanced precision medicine.<\/jats:p>","DOI":"10.1002\/advs.202413786","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T02:36:35Z","timestamp":1742697395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning\u2010Based Advanced Perspectives"],"prefix":"10.1002","volume":"12","author":[{"given":"Sung\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Hanyang University  Ansan Gyeonggi\u2010do 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Hanyang University  Ansan Gyeonggi\u2010do 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehye","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Hanyang University  Ansan Gyeonggi\u2010do 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghyeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Hanyang University  Ansan Gyeonggi\u2010do 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Nevada  Las Vegas NV 89154 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-3173","authenticated-orcid":false,"given":"Jae\u2010Yeol","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Hanyang University  Ansan Gyeonggi\u2010do 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116715"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721001185"},{"key":"e_1_2_8_2_1","first-page":"1","author":"Terlizzi E. 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