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Non\u2010invasive MRI detection offers an important diagnostic method to prevent fibrosis from progressing to cirrhosis or hepatocellular carcinoma. However, because fibrosis is confined to the periportal areas, and changes in tissue structure and stiffness are minimal, standard T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010 or T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted imaging struggles to capture these early\u2010stage lesions. To address this challenge, a highly sensitive and targeted T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010T\n                    <jats:sub>2<\/jats:sub>\n                    dual\u2010mode magnetic resonance imaging (MRI) nanoprobe is designed and developed, specifically targeting early\u2010stage liver fibrosis characterized by the activation of hepatic stellate cells (HSCs) and the overexpression of platelet\u2010derived growth factor receptor \u03b2 (PDGFR\u03b2). The nanoprobe exhibits excellent relaxivity (r\n                    <jats:sub>2<\/jats:sub>\n                    \/r\n                    <jats:sub>1<\/jats:sub>\n                    = 10.7) and precise targeting due to PDGFR\u03b2\u2010specific peptides conjugated to its protein nanocage. In vivo, imaging in animal models demonstrate effective accumulation of the probe in fibrotic regions as NAFLD progressed, with fluorescence signal intensity accurately reflecting the severity of liver fibrosis. Using a 7T MRI system, T\n                    <jats:sub>1<\/jats:sub>\n                    and T\n                    <jats:sub>2<\/jats:sub>\n                    images are overlaid within 1 h, accurately locating fibrotic areas and improving diagnostic speed and precision. The nanoprobe shows excellent biocompatibility and enhances early fibrosis detection in NAFLD, offering significant clinical potential for early diagnosis, prognosis, and recurrence monitoring.\n                  <\/jats:p>","DOI":"10.1002\/advs.202413788","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:53:40Z","timestamp":1741730020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficient and Specific PDGFR\u03b2\u2010Targeting Dual\u2010Mode T\n                    <sub>1<\/sub>\n                    \u2010T\n                    <sub>2<\/sub>\n                    MRI Nanoprobe for Early Diagnosis of Non\u2010Alcoholic Fatty Liver"],"prefix":"10.1002","volume":"12","author":[{"given":"Zehua","family":"Li","sequence":"first","affiliation":[{"name":"High Magnetic Field Laboratory Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei Anhui 230031 P. 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