{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:38:06Z","timestamp":1790786286888,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postoperative cognitive dysfunction (POCD) frequently occurs after surgery, resulting in extended hospitalizations, higher healthcare expenses, and potential long\u2010term cognitive impairment. Despite its significant impact, effective preventive and therapeutic strategies for POCD are still lacking. Neuroinflammation plays a crucial role in the pathogenesis of POCD. To address this, a H\n                    <jats:sub>2<\/jats:sub>\n                    emitter is developed that employs hydrogen\u2010gene therapy facilitated by ultrasound, allowing for the repair of the neuroinflammatory microenvironment in a spatiotemporally controllable manner to effectively prevent anesthesia\/surgery\u2010induced cognitive impairment. Utilizing focused ultrasound, the blood\u2013brain barrier can be opened in a controlled manner, enabling the efficient delivery of hydrogen emitters (HPPS) carrying siRNA to the site of neuroinflammation. On one hand, the hydrogen emitter effectively generates hydrogen to eliminate excess hydroxyl radicals; on the other hand, it utilizes siRNA to target and reduce tau protein phosphorylation. This targeted hydrogen\u2010gene therapy strategy has been demonstrated in both mouse and rat postoperative models to significantly reduce neuroinflammation and improve postoperative spatial memory as well as object recognition. This study introduces a novel and effective strategy for preventing anesthesia\/surgery\u2010induced cognitive impairment and offering new insights for the treatment of other neuroinflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202414397","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:40:17Z","timestamp":1741693217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ultrasound\u2010Assisted H\n                    <sub>2<\/sub>\n                    Transmitter Enables Hydrogen\u2010Gene Therapy to Prevent Anesthesia\/Surgery\u2010Induced Cognitive Impairment"],"prefix":"10.1002","volume":"12","author":[{"given":"Ruonan","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huashan Hospital Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Zhengzhou University  No.1, Eastern Jianshe Road Zhengzhou Henan Province 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Center of Minimally Invasive Treatment for Tumor Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-0449","authenticated-orcid":false,"given":"Huixiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Institute of Ultrasound in Medicine and Engineering Zhongshan Hospital Fudan University  Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Institute of Ultrasound in Medicine and Engineering Zhongshan Hospital Fudan University  Shanghai 200032 P. R. 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