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Herein, a versatile nanocomposite microneedle patch (referred to as GM\u2010Ag\n                    <jats:sub>2<\/jats:sub>\n                    S\/Ca\n                    <jats:sup>32<\/jats:sup>\n                    P) is designed to simultaneously eliminate residual tumor post\u2010surgery and promote the healing of infectious wounds. This microneedle patch effectively penetrates subcutaneous tissues, delivering therapeutic payloads to infiltrating tumor cells and bacteria. The Ag\n                    <jats:sub>2<\/jats:sub>\n                    S\/Ca\n                    <jats:sup>32<\/jats:sup>\n                    P nanocomposites encapsulated within the microneedle patch decompose in the acidic microenvironment of tumors and bacterial biofilms, releasing radioactive\n                    <jats:sup>32<\/jats:sup>\n                    P and Ag\n                    <jats:sub>2<\/jats:sub>\n                    S nanodots, which enhance tumor eradication and bacteria killing through synergistic brachytherapy and photothermal therapy (PTT). Moreover, the nanocomposite microneedle patch promotes scar\u2010free wound healing by reducing inflammation, and promoting granulation tissue formation, collagen deposition, and angiogenesis, thanks to localized hyperthermia, radiation, and the swelling and biodegradation of the microneedle matrices. This microneedle patch\u2010based postoperative adjuvant therapy offers a comprehensive strategy for addressing melanoma recurrence and infectious wound healing, with promising potential for clinical application in postsurgical management.\n                  <\/jats:p>","DOI":"10.1002\/advs.202414468","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T13:35:27Z","timestamp":1738676127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Biomineralized Nanocomposite\u2010Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-6062","authenticated-orcid":false,"given":"Peng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  No. 87 Xiangya Road Changsha Hunan 410008 China"},{"name":"Key Laboratory of Biological Nanotechnology  NHC. No. 87 Xiangya Road Changsha Hunan 410008 China"},{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  No. 87 Xiangya Road Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  No. 87 Xiangya Road Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  No. 87 Xiangya Road Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha Hunan 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-0833","authenticated-orcid":false,"given":"Weibo","family":"Cai","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison WI 53705 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  No. 87 Xiangya Road Changsha Hunan 410008 China"},{"name":"Key Laboratory of Biological Nanotechnology  NHC. 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