{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:46:56Z","timestamp":1792010816538,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800780"],"award-info":[{"award-number":["31800780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013153","name":"Shantou Science and Technology Project","doi-asserted-by":"publisher","award":["240513226499580"],"award-info":[{"award-number":["240513226499580"]}],"id":[{"id":"10.13039\/501100013153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Graves' disease (GD) is an autoimmune disorder with a high incidence rate, particularly affecting women of reproductive age. Current treatment modalities for GD carry significant disadvantages, especially for pregnant or nursing women. As a novel extracorporeal therapeutic technique, high\u2010intensity focused ultrasound (HIFU) shows great promise for treating GD; however, its low treatment efficacy impedes clinical application. In this study, a thyroid\u2010targeted nano\u2010bomb system (PD\u2010PLGA@Si\u2010Ab\/PDA\u2010I, PSAPI) is developed to enhance HIFU efficacy and improve therapeutic outcomes for GD. The core structure of PSAPI encapsulates a phase\u2010transition material, perfluorohexane, and the anti\u2010inflammatory drug diclofenac\u00a0within a poly(lactide\u2010co\u2010glycolide) (PLGA) and silica shell. A polydopamine coating enhances biocompatibility, while iodine loading and thyroid\u2010stimulating hormone receptor (TSHR)\u00a0antibodies grafting ensure targeted delivery to the thyroid. Robust in vitro and in vivo results demonstrated that PSAPI is highly biocompatible, accumulates in the thyroid within 24\u00a0h after administration, and significantly potentiates the therapeutic efficacy of HIFU, resulting in markedly reduced inflammatory responses. Transcriptomic analysis revealed a cellular defense mechanism activated in PSAPI\u2010treated cells following HIFU irradiation, highlighting potential molecular targets for the future development of HIFU\u2010sensitizing agents. The biocompatible PSAPI nano\u2010bomb developed in this study holds great transformative potential, addressing critical gaps in current therapeutic practices for GD.<\/jats:p>","DOI":"10.1002\/advs.202414597","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:32:41Z","timestamp":1737523961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Thyroid\u2010Targeted Nano\u2010Bombs Empower HIFU for Graves' Disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Binhao","family":"Wang","sequence":"first","affiliation":[{"name":"The Department of Head and Neck Surgery Cancer Hospital of Shantou University Medical College  Shantou Guangdong 515041 P. R. 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