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In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and glucocorticoid receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR,\n                    <jats:italic>Lama5<\/jats:italic>\n                    , is identified and confirmed in vivo and in vitro that the corticosterone\u2010GR\u2010LAMA5 axis is a significant pathway mediating chronic psychological stress\u2010induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a biomarker for myocardial hypertrophy and impaired cardiac function in patients with depression. In summary, a novel hypertrophy\u2010related gene,\n                    <jats:italic>Lama5<\/jats:italic>\n                    has been identified, that may play an important role in chronic psychological stress\u2010induced cardiomyocyte hypertrophy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202414659","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T09:39:50Z","timestamp":1752226790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone\u2010Glucocorticoid Receptor\u2010LAMA5 Axis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-1845","authenticated-orcid":false,"given":"Chuanjing","family":"Zhang","sequence":"first","affiliation":[{"name":"The Affiliated Lihuili Hospital of Ningbo University Health Science Center Ningbo University  Ningbo 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