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Although human studies have demonstrated a positive association between obesity and anxiety disorder, the exact mechanism linking these conditions is unclear. Interestingly, oxytocin (Oxt) neurons, predominantly expressed in the hypothalamic paraventricular nucleus (PVN), play a crucial role in both obesity and anxiety. In this study, obesity can induce anxiety\u2010like behavior in mice, which can be ameliorated by the activation of PVN Oxt neurons. Conversely, inhibiting PVN Oxt neurons accelerate the progression of anxiety. Moreover, the family with sequence similarity 172, member A (Fam172a), an anxiety susceptibility gene, is highly expressed in the hypothalamic PVN Oxt neuron but reduce in the PVN Oxt neuron of mice in the high\u2010fat diet and acute restraint stress conditions. Significantly, overexpression of Fam172a in PVN Oxt neurons improve obesity\u2010anxiety\u2010like behavior in mice. In contrast, disruption of Fam172a in PVN Oxt neurons exacerbate obesity\u2010anxiety\u2010like behavior. Furthermore, this study demonstrates that Fam172a is involved in mRNA degradation in Oxt neurons by regulating the intranuclear transport of Argonaute 2, thereby influencing Oxt secretion and ultimately impacting obesity\u2010anxiety\u2010like behavior. These findings suggest that Fam172a serves as a key target of PVN Oxt neurons in the regulation of obesity\u2010induced anxiety.<\/jats:p>","DOI":"10.1002\/advs.202414723","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T09:04:36Z","timestamp":1739783076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity\u2010Induced Anxiety"],"prefix":"10.1002","volume":"12","author":[{"given":"Baocheng","family":"Wan","sequence":"first","affiliation":[{"name":"Jinzhou Medical University Graduate Training Base Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School 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