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These reactions typically involve the activation of innate immunity and the initiation of an inflammatory response, which can persist as chronic inflammation, causing\u00a0implant failure. To reduce these risks, various strategies have been developed to modify the material composition, surface characteristics, or mechanical properties of biomaterials. Moreover, bioactive materials have emerged as a new class of biomaterials that can induce desirable tissue responses and form a strong bond between the implant and the host tissue. In recent years, different immunomodulatory strategies\u00a0have been incorporated into biomaterials as drug delivery systems. Furthermore, more advanced molecule and cell\u2010based immunomodulators have been developed and integrated with biomaterials. 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