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This study elucidates the structure\u2010mechanical properties and mechanobiology of the PCM in fibrocartilage, using the murine meniscus as the model. The fibrocartilage PCM is comprised of thin, randomly oriented collagen fibrils that entrap proteoglycans, contrasting with the densely packed, highly aligned collagen fibers in the bulk extracellular matrix (ECM). Compared to the ECM, the PCM exhibits lower modulus and greater isotropy, but has similar relative viscoelastic properties. In\n                    <jats:italic>\n                      Col5a1\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    menisci, the reduction of collagen V results in thicker, more heterogeneous collagen fibrils, reduced modulus, loss of isotropy and faster viscoelastic relaxation in the PCM. Such altered PCM leads to impaired matrix\u2013to\u2013cell strain transmission, and in turn, disrupts mechanotransduction of meniscal cells, as illustrated by reduced calcium signaling activities and alters expression of matrix genes. In vitro,\n                    <jats:italic>\n                      Col5a1\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    cells produce a weakened PCM with inferior properties and reduced protection of cells against tensile stretch. These findings highlight the PCM as a distinctive microstructure in fibrocartilage mechanobiology, underscoring a pivotal role of collagen V in PCM function. Targeting the PCM or its constituents offers potential for improving meniscus regeneration, osteoarthritis intervention and broader fibrocartilage\u2010related therapies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202414750","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:49:41Z","timestamp":1747986581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen"],"prefix":"10.1002","volume":"12","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Science and Health Systems Drexel University  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Science and Health Systems Drexel University  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Chin","family":"Heo","sequence":"additional","affiliation":[{"name":"McKay Orthopaedic Research Laboratory Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani School of Medicine University of South Florida  Tampa FL 33612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Science and Health Systems Drexel University  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Science and Health Systems Drexel University  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Science and Health Systems Drexel University  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Loebel","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Burdick","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute and Department of Chemical and Biological Engineering University of Colorado  Boulder CO 80309 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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