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KBC control is still challenging owing to the evolution of resistant populations of <jats:italic>Psa<\/jats:italic>, the environmental risks associated with copper bactericides, and lack of effective bactericides. Therefore, to develop novel and efficient bactericides against <jats:italic>Psa<\/jats:italic>, a matrine (MT)\u20105\u2010methylsalicylic acid (5\u2010OMESA) salt (MOS) is synthesized and its antibacterial activity is analyzed. The newly synthesized compound is more antibacterial against <jats:italic>Psa<\/jats:italic> than the commercial bactericide thiazole copper (TC). MOS significantly disrupts the membrane structure of <jats:italic>Psa<\/jats:italic> and penetrates the cells more efficiently. In addition, it has high affinities to the <jats:italic>Psa<\/jats:italic> FtsZ protein and DNA helicase, which probably contribute to its bactericidal activity. Subsequently, the encapsulation of MOS into a supramolecular nanocarrier hydroxypropyl\u2010\u03b2\u2010cyclodextrin (HPCD) and the fabrication of a nano formulation (MOS@HPCD) result in superior solubility, penetration, foliar deposition and wettability, sustained release, and prolonged protection against <jats:italic>Psa<\/jats:italic>. The in vitro and in vivo control efficiencies of MOS@HPCD against <jats:italic>Psa<\/jats:italic> are markedly enhanced compared to those of MOS. This study proposes a promising supramolecular material to control KBC.<\/jats:p>","DOI":"10.1002\/advs.202414752","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T07:34:42Z","timestamp":1748072082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Supramolecular Material for Controlling Kiwifruit Bacterial Canker"],"prefix":"10.1002","volume":"12","author":[{"given":"Xile","family":"Deng","sequence":"first","affiliation":[{"name":"Hunan Academy of Agricultural Sciences  Changsha 410125 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Bian","sequence":"additional","affiliation":[{"name":"National Pesticide Engineering Research Center (Tianjin) College of Chemistry Nankai University  Tianjin 300071 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