{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:55Z","timestamp":1792670815894,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016073","name":"Key Technologies Research and Development Program of Anhui Province","doi-asserted-by":"publisher","award":["2023YFD1801100"],"award-info":[{"award-number":["2023YFD1801100"]}],"id":[{"id":"10.13039\/100016073","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endometritis, a prevalent reproductive system disease with high incidence, leads to reproductive dysfunction in humans and animals, causing huge economic losses. Dimethyl itaconate (DI) has been demonstrated to exert protective effects in multiple inflammatory diseases. Nevertheless, the efficacy of DI in preventing endometritis and the role played by the gut microbiota remain unknown. In this study, it is found that DI ameliorated\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli)<\/jats:italic>\n                    induced endometritis in mice. The protective effect is abolished by antibiotic\u2010induced depletion of the gut microbiota, and fecal microbiota transplantation (FMT) from DI\u2010treated mice to recipient mice ameliorated\n                    <jats:italic>E. coli<\/jats:italic>\n                    \u2010induced endometritis. Integrative multiomics reveals that DI promotes the multiplication of\n                    <jats:italic>norank_f_Muribaculaceae<\/jats:italic>\n                    in vivo, and supplementation of\n                    <jats:italic>Muribaculum intestinale<\/jats:italic>\n                    (DSM 28989), which belongs to the\n                    <jats:italic>norank_f_Muribaculaceae<\/jats:italic>\n                    genus, upregulates the level of guanosine in the uterus. Mechanistically, the protective effect of guanosine in endometritis is mediated by activating the expression of\n                    <jats:italic>CXCL14<\/jats:italic>\n                    in uterine epithelial cells. Moreover, the antibody\u2010neutralizing experiment of CXCL14 eliminated this protective effect. In conclusion, this study elucidates the significant role of the gut microbiota and its metabolites in the protection of DI against endometritis, and provides new evidence for the regulation of distal organ by the gut microbiota.\n                  <\/jats:p>","DOI":"10.1002\/advs.202414792","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T12:44:31Z","timestamp":1744634671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dimethyl Itaconate Alleviates\n                    <i>Escherichia coli<\/i>\n                    \u2010Induced Endometritis Through the Guanosine\u2010CXCL14 Axis via Increasing the Abundance of\n                    <i>norank_f_Muribaculaceae<\/i>"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuhang","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapei","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linkai","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuxi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-7516","authenticated-orcid":false,"given":"Yongguo","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University  Changchun 130062 China"},{"name":"Department of Clinical Veterinary Medicine College of Veterinary Medicine Jilin University  Changchun 130062 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01458-3"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1230837"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(00)00410-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2020.g440"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.02.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02963J"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12316"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01768-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01352-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112658"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01471-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0052-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01028-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4185"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00890-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi6087"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.01.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00690-y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02290-2023"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202205-0893OC"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.10.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1351899"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07282-7"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1333"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867311209066126"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2018.10.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120129"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13454"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.748375"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.938979"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13424"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223490"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/535047a"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09125"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62046"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002112"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129605"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2192478"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0242-7"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18309"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00501-9"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13085"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052406"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.103021"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.3c00562"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0506-9"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.06.022"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136928"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c00515"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7650978"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2431705"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157874"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12192719"},{"key":"e_1_2_9_60_1","volume":"10","author":"Zhao C.","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01402-z"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113919"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17558"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.05.007"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.08.028"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202414792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:44:18Z","timestamp":1759743858000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202414792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":65,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/advs.202414792"],"URL":"https:\/\/doi.org\/10.1002\/advs.202414792","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2414792"}}