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However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro\u2010vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life\u2010threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio\u2010temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients.<\/jats:p>","DOI":"10.1002\/advs.202415235","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T13:54:16Z","timestamp":1738590856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ultrasound Super\u2010Resolution Imaging of Neonatal Cerebral Vascular Reorganization"],"prefix":"10.1002","volume":"12","author":[{"given":"Simone","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Medicine Sana Clinics Duisburg  Zu den Rehwiesen 9 47055 Duisburg Germany"},{"name":"Department of Pediatrics I University Hospital Essen University of Duisburg\u2010Essen  Hufelandstra\u00dfe 55 45147 Essen Germany"},{"name":"Centre for Translational Neuro\u2010 and Behavioral Sciences University Hospital Essen University of 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