{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:02:14Z","timestamp":1790971334283,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Current treatments for autoimmune diseases often involve broad\u2010acting immunosuppressants, which carry risks such as infections and malignancies. This study investigates whether exosomes derived from anti\u2010inflammatory macrophages (AE) and decorated with myelin oligodendrocyte glycoprotein (MOG) peptide (AE\/M) can induce immune tolerance in autoimmune diseases. Experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, serves as the autoimmune disease model. Exosomes derived from myoblasts or fibroblasts are also modified with MOG peptides for comparison. Unlike their myoblast or fibroblast counterparts, exosomes from anti\u2010inflammatory macrophages demonstrate a targeted capacity toward antigen\u2010presenting cells. Moreover, AE\/M uniquely promotes the differentiation of dendritic cells (DC) into a tolerogenic phenotype. When splenocytes are treated with AE\/M, an increased population of tolerogenic DC (tolDC) is observed, even under proinflammatory stimuli. Subcutaneous administration of AE\/M in the EAE mouse model results in MOG peptide\u2010specific immune tolerance and preserves motor coordination. In contrast to treatments with fibroblast\u2010 or myoblast\u2010derived exosomes modified with MOG peptides, AE\/M treatment provides complete protection from EAE in mice. These findings highlight the potential of self\u2010antigen modified AE as a versatile and adaptable nanoplatform for the treatment of various autoimmune diseases.<\/jats:p>","DOI":"10.1002\/advs.202415265","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T12:40:01Z","timestamp":1739364001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anti\u2010Inflammatory Macrophage\u2010Derived Exosomes Modified With Self\u2010Antigen Peptides for Treatment of Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Qiaoyun","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwon","family":"Park","sequence":"additional","affiliation":[{"name":"College 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