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Circular RNAs (circRNAs) play important regulatory roles in the development of atherosclerosis. However, the biological functions and potential molecular mechanisms of circRNAs in HHcy\u2010induced lipid accumulation leading to atherosclerosis are still unclear. In this study, it is determined that homocysteine (Hcy) downregulates the expression of circ\u2010PIAS1\u20105 by global circRNA expression profiling and that circ\u2010PIAS1\u20105 inhibits Hcy\u2010mediated lipid accumulation in foam cells and the pathogenesis of atherosclerosis by acting as a sponge for miR\u2010219a\u20102\u20103p. Circ\u2010PIAS1\u20105 is identified as a potential diagnostic biomarker of HHcy\u2010associated atherosclerosis in male \u201capolipoprotein E knockout (ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    )\u201d mice. Mechanistically, circ\u2010PIAS1\u20105 activates the adenosine 5\u2018\u2010monophosphate (AMP)\u2010activated protein kinase pathway by regulating TEAD1 through miR\u2010219a\u20102\u20103p, and Hcy mediates the m\n                    <jats:sup>6<\/jats:sup>\n                    A modification and nuclear export of circ\u2010PIAS1\u20105 via YTHDC1 to increase lipid accumulation in foam cells and accelerate the pathogenesis of atherosclerosis. Taken together, these results highlight the role of circ\u2010PIAS1\u20105 in the Hcy\u2010mediated pathogenesis of atherosclerosis and suggest its potential application as a prognostic biomarker of atherosclerosis induced by HHcy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202415563","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:20:16Z","timestamp":1742098816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ\u2010PIAS1\u20105\/miR\u2010219a\u20102\u20103p\/TEAD1 Axis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4470-0984","authenticated-orcid":false,"given":"Shengchao","family":"Ma","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research Ningxia Medical University  Yinchuan 750004 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