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Reductive carbonylation of CO\n                    <jats:sub>2<\/jats:sub>\n                    is a powerful method to provide high\u2010value heterocycles quickly. However, examples of transition metal\u2010catalyzed carbonylation to produce flavones using CO\n                    <jats:sub>2<\/jats:sub>\n                    are quite scarce, and the related copper\u2010catalyzed carbonylative cyclization of CO\n                    <jats:sub>2<\/jats:sub>\n                    is not reported. Here, a general procedure is developed for the copper\u2010catalyzed carbonylative C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2010H bond synthesis of flavone using CO\n                    <jats:sub>2<\/jats:sub>\n                    as the C1 source. Additionally,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010labeled flavones are successfully synthesized using [\n                    <jats:sup>13<\/jats:sup>\n                    C]\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    , demonstrating significant inhibitor activity against MCF\u20107 cells in antitumor assays. Mechanistic investigations suggest that the phenolic group accelerates CO\n                    <jats:sub>2<\/jats:sub>\n                    mass transfer by promoting nucleophilic addition to DBU\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    complexes, followed by selective intramolecular carbonylative cyclization.\n                  <\/jats:p>","DOI":"10.1002\/advs.202415795","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:44:05Z","timestamp":1739238245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Copper\u2010Catalyzed Carbonylative Cyclization of CO\n                    <sub>2<\/sub>\n                    : A Promising Approach for Synthesis of Flavone"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-4320","authenticated-orcid":false,"given":"Zijun","family":"Huang","sequence":"first","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyong","family":"Dong","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadi","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yi","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjun","family":"Fang","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Rechemistry, College of Chemistry and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Medicine and Health Sciences  Shanghai 201318 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-1418","authenticated-orcid":false,"given":"Yuehui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Smart Energy Shanghai Jiao Tong University  Shanghai 200240 P. R. China"},{"name":"Carbon\u2010Negative Synthetic Biology for Biomaterial Production from CO2 (CNSB) Campus for Research Excellence and Technological Enterprise (CREATE)  1 CREATE Way Singapore 138602 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01720"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186528"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1317159"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10934-013-9729-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc01290d"},{"key":"e_1_2_8_6_1","first-page":"809","volume":"49","author":"Bildung Z.","year":"1916","journal-title":"Eur. J. Inorg. 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