{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:38:07Z","timestamp":1770755887356,"version":"3.50.0"},"reference-count":27,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2023QNB15"],"award-info":[{"award-number":["YG2023QNB15"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752046"],"award-info":[{"award-number":["2024M752046"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor in adults with high mortality rate. Recently, immunotherapy has shown great success in other tumors, however, its therapeutic effect in UM is unsatisfactory, possibly due to the insufficient immune cell infiltration and low immunogenicity of UM. Thus, an efficient therapeutic strategy to reverse the immunosuppressive tumor microenvironment is required. Herein, a PD\u2010L1 modified hierarchical structure consisting of a magnetic Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    core and spiky silica shell (MNP@Spiky\/PD\u2010L1) is developed to reverse the immunosuppressive tumor microenvironment and trigger powerful antitumor immune responses. The MNP@Spiky can induce enhanced immunogenic cell death as well as physical activation of innate immunity. First, tumor cells are disrupted directly by magnetic hyperthermia effect and released tumor\u2010associated antigens to initiate anti\u2010tumor immune responses. Meanwhile, the spiky surface of MNP@Spiky augmented tumor antigen uptake as well as maturation of dendritic cells through inflammasome activation. By further associating with PD\u2010L1\u2010targeting antibody, MNP@Spiky\/PD\u2010L1 reversed the immunosuppressive tumor microenvironment and triggered powerful antitumor immune responses. Overall, this synergistic therapeutic strategy effectively reprogramed tumor microenvironment and achieved tumor eradication, which sheds light on clinical UM immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202415868","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:10:21Z","timestamp":1739887821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unlocking the Promise of Antitumor Hyperthermia\u2010Immunotherapy with Spiky Surface Topology"],"prefix":"10.1002","volume":"12","author":[{"given":"Muyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Laboratory of Advanced Materials Fudan University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongxin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Laboratory of Advanced Materials Fudan University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-3969","authenticated-orcid":false,"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Shanghai Jiao Tong University  Shanghai 200011 China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00605"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03274"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00550"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01805"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103485"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00572-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206121"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192461099"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201707112"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25990-w"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn2941"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133094"},{"key":"e_1_2_7_13_1","volume":"14","author":"Fadel C. 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