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Similarly, biothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) are integral to many physiological and pathological processes due to their strong redox properties. Simultaneous discrimination and detection of ATP and biothiols offer valuable insights into the pathogenesis of conditions such as epilepsy and liver injury. This study introduces the first fluorescent probe,\n                    <jats:bold>BCR<\/jats:bold>\n                    , designed for multifunctional detection of ATP, GSH, Hcy, and Cys. With outstanding optical properties, excellent biocompatibility, high selectivity, and superior sensitivity, probe\n                    <jats:bold>BCR<\/jats:bold>\n                    enables effective imaging of ATP and biothiol dynamics in vivo. Moreover, probe\n                    <jats:bold>BCR<\/jats:bold>\n                    successfully visualizes changes in ATP, GSH, Hcy, and Cys levels in a PTZ\u2010induced epileptic zebrafish model and an APAP\u2010induced mouse liver injury tissue section model. These findings underscore the significant potential of probe\n                    <jats:bold>BCR<\/jats:bold>\n                    for early disease diagnosis and therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/advs.202415882","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:24:56Z","timestamp":1738232696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Multifunctional Fluorescent Probe for Simultaneous Detection of ATP, Cys, Hcy, and GSH: Advancing Insights into Epilepsy and Liver Injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Ting","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Interdisciplinary Studies Hunan Normal University  Changsha 410081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of 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