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While the clinical value and mechanistic action of the therapy is debated considerably in recent years, preclinical chronic studies employing rodent models can provide invaluable insights regarding the balance between efficacy and complications as well as mechanistic understanding of SCS therapy. However, current rodent compatible devices require tethered power delivery or bulky batteries, severely limiting the ability to probe long\u2010term efficacy of SCS therapy. This work introduces a tether\u2010free, small\u2010footprint, fully implantable, battery\u2010free SCS device compatible with rodent models, capable of delivering electrical stimulation to the spinal cord at a wide range of frequency, amplitude, and period via wireless communication adjustable on\u2010demand without direct interaction with the animal. The presented device features capabilities of clinical SCS devices, with materials and processes amendable to scalable fabrication at a cost suitable for one\u2010time use enabling high N studies. In this proof of concept, the implantable device serves to assess therapeutic efficacy of various clinically relevant SCS paradigms in alleviating neuropathic pain. This technology offers chronic stability and the potential to serve as the foundation for future research into the development of SCS therapeutic systems.<\/jats:p>","DOI":"10.1002\/advs.202415963","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T14:47:50Z","timestamp":1743864470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chronic, Battery\u2010Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-7853","authenticated-orcid":false,"given":"Allie J.","family":"Widman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Washington University School of Medicine  St. Louis MO 63110 USA"},{"name":"Washington University Pain Center Washington University School of Medicine  St. Louis MO 63110 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