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However, \u00a0the structural component alterations and immune cell infiltration characteristics of choroid plexus (ChP) following traumatic brain injury (TBI) remain incompletely understood. Here, using single\u2010cell RNA sequencing and histological analysis, the accumulation of group 2 innate lymphoid cell (ILC2) in the ChP stroma post\u2010TBI is identified. Intracerebroventricular adoptive transfer of ILC2 is further indicated to exhibit a tendency to colonize the ChP and significantly alleviate pathogenic immune infiltration during the acute phase of TBI, as well as maintain hippocampal integrity during the chronic phase. Sensory\u2010motor function and memory impairments in TBI mice are also improved under ILC2 treatment. Mechanistically, ILC2 is induced by ChP fibroblasts derived IL33 and anchored to stroma fibroblasts via the VCAM\u20101\/Integrin \u03b14\u03b27 pathway. Furthermore, single\u2010nucleus RNA sequencing of the hippocampus reveals that ILC2\u2010derived AREG promotes the initiation of neurogenesis by interacting with EGFR on early\u2010stage neurogenic cells. Overall, these findings highlight that ChP\u2010resident ILC2, through optimizing the immune microenvironment and promoting neurogenesis after TBI, may represent a potential therapeutic strategy.<\/jats:p>","DOI":"10.1002\/advs.202415984","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T03:59:38Z","timestamp":1751515178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Choroid Plexus Fibroblast\u2013ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Shiqi","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China"},{"name":"Clinical Research Center for Neurological Diseases of Zhejiang Province Hangzhou 310009 China"},{"name":"Zhejiang Key Laboratory of Research and 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