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Yet, the roles of eosinophils in TMJOA remain unclear, underscoring the need for further investigation into their potential impact and mechanism. Addressing the clinical observation that eosinophil numbers in synovial fluid are higher in healthy individuals than in those with TMJOA, the vital regulation of this cell population in TMJOA by using an ovalbumin (OVA)\u2010induced hyper\u2010eosinophilia asthma rats is explored and a rat model of antibody\u2010mediated eosinophil depletion in vivo, and co\u2010culture system of synovial fibroblasts, chondrocytes, and eosinophils in vitro. The abnormal synovial proliferation, cartilage degradation, and subchondral bone erosion are effectively inhibited in OVA\u2010induced asthmatic rats appearing in the local accumulation of eosinophils in the synovium. Conversely, the reduction in synovial eosinophils exacerbated TMJOA in rats treated with TRFK. Mechanistically, the protective effect of eosinophils against TMJOA is attributed to their promotion of Lumican secretion in the synovium, where Lumican binds to Annexin A1 in chondrocytes, inhibits transforming growth factor \u03b22 Annexin A1 and Smad2\/3 phosphorylation. These results illustrate OVA\/IL\u20105\u2010induced eosinophils\u2019 crucial role in TMJOA, identifying Lumican as a key anti\u2010TMJOA target. Collectively, these findings revealed the signature and mechanism in eosinophils that stimulate TMJOA resolution.<\/jats:p>","DOI":"10.1002\/advs.202416030","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T01:36:10Z","timestamp":1742866570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Eosinophils\u2010Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF\u2010\u03b2 Pathway Mediated by Anxa1 Binding"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenqian","family":"Chen","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial &amp; Stomatological Key Lab of Fujian College and University School and Hospital of Stomatology Fujian Medical University  Fuzhou Fujian 350002 P. R. 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