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To address this, a NIR\u2010activated heavy\u2010atom\u2010free photosensitizer (named Cy\u2010BF) is developed. Cy\u2010BF is then encapsulated with phospholipids and platelet exosome vesicles to create platelet exosomes vesicles biomimetic and Cy\u2010BF loaded hybrid liposomes (named CHL) Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation\u2010induced broadening of absorption spectra and NIR (760\u00a0nm laser) activates photothermal therapy and type I photodynamic therapy. The CHL\u2010mediated phototherapy induces mitochondrial damage and immunogenic cell death in tumor cells, decreases lactate production, and alters the tumor microenvironment by reducing regulatory T cells and increasing CD8<jats:sup>+<\/jats:sup> T cells. 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This combination approach represents a novel strategy for reversing lactate metabolism in both tumor cells and T cells, paving the way for future clinical applications in photoimmunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202416143","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:07:39Z","timestamp":1741590459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy\u2010Atom\u2010Free Photosensitizers\u2010Based Combination Therapies to Boost Cancer Photoimmunotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Yongjian","family":"Zhang","sequence":"first","affiliation":[{"name":"The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang 150000 P. R. 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