{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:19:50Z","timestamp":1790198390104,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    , a prevalent eukaryotic microorganism in the gut microbiota, has emerged as a potential link between healthy diets and improved cardiometabolic health. Despite its genetic diversity and varied host interactions,\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    is consistently associated with healthier dietary patterns and reduced risk of cardiometabolic diseases. Current evidence suggests that\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    may influence host metabolism by modulating gut microbial composition, short\u2010chain fatty acids (SCFAs) production, and immune cell differentiation. Moreover, its role in tryptophan metabolism provides intriguing insights into its potential impact on host signaling pathways. However, mechanistic evidence connecting\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    to improved metabolic health remains limited. This perspective explores plausible pathways, including SCFAs\u2010mediated signaling, tryptophan metabolism, and immune modulation, through which\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    may exert its effects. A systematic research framework integrating axenic cultivation, in vitro co\u2010culture systems, animal models, and multi\u2010omics approaches is proposed to further elucidate these mechanisms and expand the understanding of\n                    <jats:italic>Blastocystis<\/jats:italic>\n                    in gut health and disease.\n                  <\/jats:p>","DOI":"10.1002\/advs.202416325","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T14:54:08Z","timestamp":1743864848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Decoding\n                    <i>Blastocystis<\/i>\n                    \u2010Driven Mechanisms in Gut Microbiota and Host Metabolism"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-6180","authenticated-orcid":false,"given":"Lei","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences  Shanghai 200241 China"},{"name":"Broad Institute of MIT and Harvard  Cambridge MA 02142 USA"},{"name":"Center for Computational and Integrative Biology Massachusetts General Hospital  Boston MA 02134 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-729X","authenticated-orcid":false,"given":"Kevin SW","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Parasitology Healthy Longevity Translational Research Programme and Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore  Singapore 117545 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