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Despite major advances in neural interface technology, there are limited options for neural inhibition. Here, a microchip\u2010based implantable micro\u2010coil device is presented to achieve high spatial precision for cortical inhibition. Cortical in vivo two\u2010photon imaging of spontaneous neural activity showed \u00b5MS reversibly suppressed single cells, and as \u00b5MS magnitude is increased, the suppressed cell population increased from 14% to 41%. At the circuit level, the average suppressed area is 0.05 mm\n                    <jats:sup>2<\/jats:sup>\n                    , seven times smaller than the activated area induced by micro\u2010electrode stimulation (\u00b5ES). It is discovered that neurons responded more strongly to \u00b5MS than to \u00b5ES, which is exploited to effectively neutralize the neural excitation induced by concurrently delivered strong \u00b5ES (80\u00a0\u00b5A). Moreover, \u00b5MS mitigates hyperactive neural firing caused by pharmacologically induced seizures, reducing seizure amplitude by 54%. These findings underscore the potential of \u00b5MS as a precise, effective, and versatile tool for localized neuromodulation with an effect of opposite polarity from \u00b5ES. Complementing optogenetic and electrical stimulation for multi\u2010functional neural interfaces, \u00b5MS holds promise as a unique neuroscience research tool and as a potential therapeutic intervention method for precisely suppressing hyperactive brain circuits.\n                  <\/jats:p>","DOI":"10.1002\/advs.202416771","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:41:45Z","timestamp":1748335305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Micro\u2010Coil Neuromodulation at Single\u2010Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-9429","authenticated-orcid":false,"given":"Kayeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neuroscience Faculty of Health and Medical Science University of Copenhagen  Copenhagen DK\u20102200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Faculty of Health and Medical Science University of Copenhagen  Copenhagen DK\u20102200 Denmark"},{"name":"Department of Civil and Mechanical Engineering Technical University of Denmark  Lyngby 2800 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingdong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Civil and Mechanical Engineering Technical University of Denmark  Lyngby 2800 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Faculty of Health and Medical Science University of Copenhagen  Copenhagen DK\u20102200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendoline A. 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