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Successfully reconstructing the complex and dynamic mechanical microenvironments of human tissues necessitates innovative biomaterial designs that surpass conventional approaches. This review provides a comprehensive overview of recent advances in the field of biomaterial\u2010mediated mechanomodulation of stem cell fate, encompassing both mechanobiological dynamics and dynamic mechanomodulatory biomaterials. It is also discussed how specific material properties, such as stiffness, nanotopography, shear stress, and dynamic stimuli\u2010responsive behavior, can be used to precisely control stem cell processes, including proliferation, differentiation, migration, and apoptosis. Furthermore, the application of these strategies is examined in both conventional and advanced culture systems, such as organoids and organ\u2010on\u2010chip platforms, with a particular focus on tissue\u2010engineering applications in the neurological, musculoskeletal, and endocrine systems. 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