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Acute oral administration of DON elicits a dose\u2010responsive reduction in food intake, accompanied by pronounced alterations in locomotor activity and feeding frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, by targeting of GABA neurons in the CeA. Following exposure to DON, an increase in connectivity between the paraventricular nucleus of the thalamus (PVT) and CeA<jats:sup>GABA<\/jats:sup> neurons is observed, suggesting the involvement of this pathway in DON's adverse effects on feeding and emotional states. Chemogenetic and optogenetic manipulations of CeA<jats:sup>GABA<\/jats:sup> neurons resulted in substantial alterations in mice's feeding and overall activity. These findings suggest that CeA<jats:sup>GABA<\/jats:sup> neurons are involved in DON\u2010induced anorexia and aversive\u2010like emotional responses. Additionally, the administration of the SCN10A antagonist (A\u2010803467) effectively mitigated DON\u2010induced anorexia and aversive\u2010like emotions, highlighting the pivotal role of the PVT\u2010CeA circuit and CeA<jats:sup>GABA<\/jats:sup> neurons in regulating the physiological and emotional impacts of DON. These findings have significant implications for public health and clinical interventions, offering potential therapeutic strategies to mitigate DON's adverse effects on human health.<\/jats:p>","DOI":"10.1002\/advs.202417068","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:38:20Z","timestamp":1741747100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regulation of PVT\u2010CeA Circuit in Deoxynivalenol\u2010Induced Anorexia and Aversive\u2010Like Emotions"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-6449","authenticated-orcid":false,"given":"Liu\u2010Nan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Tongji Medical College Huazhong University of Science and Technology  Hangkong Road 13 Wuhan 430030 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