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The pathogenesis of psoriasis is closely associated with metabolic disorders, while therapies targeting the dysregulated metabolism in psoriasis remain limited. Therefore, exploring the pathogenesis of psoriasis and identifying potential metabolic therapeutic targets is imperative. In this study, potential biomarkers for clinically targeted metabolic therapies in patients with psoriasis are aimed to be identified. RNA\u2010sequencing analysis is performed on metabolism\u2010related genes to identify differentially expressed metabolism\u2010related genes. Then, various bioinformatics analyses and comprehensive functional experiments are conducted to verify the roles of the identified genes. A key gene\n                    <jats:italic>SLC16A10<\/jats:italic>\n                    is identified with significant diagnostic and therapeutic potential for psoriasis.\n                    <jats:italic>SLC16A10<\/jats:italic>\n                    is likely involved in arachidonic acid metabolism in keratinocytes through regulating thyroid hormone homeostasis, contributing to the development of psoriasis.\n                    <jats:italic>SLC16A10<\/jats:italic>\n                    represents a promising therapeutic target for guttate psoriasis and can improve the outcomes of existing immune\u2010targeted therapeutic agents. Comprehensive in vitro and in vivo experiments confirm that\n                    <jats:italic>SLC16A10<\/jats:italic>\n                    downregulation alleviates the severity of psoriasis and hyperinflammation. Moreover,\n                    <jats:italic>SLC16A10<\/jats:italic>\n                    may induce one of the sequelae of psoriasis, namely post\u2010inflammatory hypopigmentation, by inhibiting melanogenesis. These findings demonstrate the potential of SLC16A10 as a diagnostic biomarker and therapeutic target for psoriasis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417093","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:10:49Z","timestamp":1757329849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0880-5504","authenticated-orcid":false,"given":"Jingyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Air Force Medical Center PLA  Beijing 100142 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Air Force Medical Center PLA  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