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Semaphorin 3E (Sema3E)\u2010Plexin\u2010D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown. Evidence indicates that Sema3E\u2010Plexin\u2010D1 pathway plays an important role in the mouse ovary. The expression of Sema3E and its receptor, Plexin\u2010D1, is dynamically regulated in the mouse ovary downstream of the LH surge. This regulation requires the modulation of chromatin accessibility by CCAAT\/enhancer\u2010binding proteins \u03b1 and \u03b2. Intraovarian injection of recombinant Sema3E results in reduced ovulation, impaired corpus luteum formation, and aberrant ovarian angiogenesis. These in vivo physiological abnormalities are consistent with altered expression of genes regulating these processes, and with data from in vitro cultured granulosa cells and ovarian stromal tissues treated with Sema3E or neutralizing antibody of Plexin\u2010D1. The findings pinpoint Sema3E\u2010Plexin\u2010D1 pathway as a potential therapeutic target for fertility and infertility management.<\/jats:p>","DOI":"10.1002\/advs.202417163","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:50:32Z","timestamp":1747727432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Semaphorin 3E\u2010Plexin\u2010D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4624-303X","authenticated-orcid":false,"given":"Hanxue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Animal Science College of Agriculture and Life Sciences Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Soloway","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY 14853 USA"},{"name":"Division of Nutritional Sciences College of Agriculture and Life Sciences Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY 14853 USA"},{"name":"Division of Nutritional Sciences College of Agriculture and Life Sciences Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Grenier","sequence":"additional","affiliation":[{"name":"Genomics Innovation Hub Biotechnology Resource Center Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Munn","sequence":"additional","affiliation":[{"name":"Genomics Innovation Hub Biotechnology Resource Center Cornell University  Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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