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Considering the crucial role of ROS in SALI, a Pd doped CeO\n                    <jats:sub>2<\/jats:sub>\n                    (CP) nano\u2010heterojunction with enhanced ROS scavenging capacity is developed to act as a catalytic nanomedicine for the treatment of SALI. Combining with near infrared (NIR) irradiation, it exhibits excellent scavenging capacity of ROS including hydroxyl radical (\u2022OH), superoxide anion (\u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), as well as singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) for CP. Significantly, it also demonstrates the excellent antioxidant and anti\u2010inflammatory activities for lipopolysaccharides (LPS) stimulated macrophages (RAW264.7), and cecum ligation and puncture (CLP) treated C57BL\/6J mice via reducing intracellular ROS levels, decreasing inflammatory factors expression levels, as well as activating Keap1\/Nrf\u20102\/HO\u20101 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation and promote liver tissue repair, finally achieving the alleviation of SALI. It provides a promising therapeutic strategy of CP+NIR with high efficacy and biosafety for the management of SALI.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417252","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:08:54Z","timestamp":1751242134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["NIR Driven Pd\/Cerium Oxide Nano\u2010Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy"],"prefix":"10.1002","volume":"12","author":[{"given":"Tao","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Emergency Guangxi Medical University Cancer Hospital  Nanning Guangxi 530201 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Qin","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The Second Affiliated 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