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Five single\u2010cell and two bulk RNA\u2010seq datasets are integrated to screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription (\n                    <jats:italic>SP1)<\/jats:italic>\n                    is identified as a specific regulator of\n                    <jats:italic>Plac1<\/jats:italic>\n                    , which is confirmed by cleavage under targets and tagmentation (CUT&amp;Tag)\u2010seq. With in vitro experiments, in vivo subcutaneous tumor, and a transgenic autochthonous tumor model, it is revealed that\n                    <jats:italic>Plac1<\/jats:italic>\n                    expression promotes HNSCC progression by inducing epidermal growth factor receptor endocytosis and recycling to increase PI3K\/AKT signaling pathway activity. Then, it is revealed that\n                    <jats:italic>\n                      Plac1\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    tumor cells recruit CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells via CXCL11\/CXCR3 and induce Treg differentiation via PVR\/TIGIT, which in turn activates the tumorigenic signaling of\n                    <jats:italic>\n                      Plac1\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    tumor cells via LTA\/LTBR and forms a reciprocal protumor loop. These findings provide insights into molecular features of CTAs in HNSCC and facilitate the development of personalized treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417312","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:54:45Z","timestamp":1741726485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Plac1\n                    <sup>+<\/sup>\n                    Tumor Cell\u2010Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaoyan","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial &amp; Head and Neck Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology  Shanghai 200011 P. 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