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Lipid droplet is a type of organelles that regulates lipid metabolism and oxidative stress. And the regulatory mechanisms of lipid droplets on spinal cord injury remain unclear. Herein, it is found that GTPase\u00a0activation of Annexin A7 (ANXA7) promotes the up\u2010regulation of genes related to lipid droplet formation. ANXA7 can interact with peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) to enhance the stability of PPAR\u03b3, and promote lipid droplet formation and interaction with mitochondria through promoting Perilipin 5 expression. Then, oxidative stress and lipid peroxidation are inhibited due to the promotion of nuclear factor erythroid 2\u2010related factor 2 (NRF2) nuclear translocation and expression of glutathione peroxidase 4 (GPX4). ANXA7 activation promotes lipid droplet formation and mitochondria\u2010lipid droplet interaction by enhancing nuclear translocation of PPAR\u03b3, which contributes to inhibiting lipid peroxidation and neuron damage. Furthermore, activation of PPAR\u03b3 can promote neural function recovery and spinal cord repair in mice. The focus of this study is to investigate the effects of lipid droplets regulated by ANXA7\/PPAR\u03b3, providing new targets and strategies for spinal cord injury.<\/jats:p>","DOI":"10.1002\/advs.202417326","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:05:36Z","timestamp":1740539136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lipid Droplets Metabolism Mediated by ANXA7\u2010PPAR\u03b3 Signaling Axis Regulates Spinal Cord Injury Repair in Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Lu","family":"Chen","sequence":"first","affiliation":[{"name":"Orthopaedic Research Center of Shandong University Department of orthopaedics Qilu Hospital of Shandong University #107 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Shandong University #44 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center of Shandong University Department of orthopaedics Qilu Hospital of Shandong University #107 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Shandong University #44 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center of Shandong University Department of orthopaedics Qilu Hospital of Shandong University #107 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center of Shandong University Department of orthopaedics Qilu Hospital of Shandong University #107 Wenhua West Road 250012 Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-138X","authenticated-orcid":false,"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center of Shandong University Department of orthopaedics Qilu Hospital of Shandong University #107 Wenhua West Road 250012 Jinan Shandong China"},{"name":"The Second Hospital of Shandong University #247 Beiyuan Street Jinan Shandong 250000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105694"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0068-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01663-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0270-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1516539"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9600-5"},{"key":"e_1_2_10_8_1","first-page":"711","volume":"38","author":"Ren X. 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