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The parasubthalamic nucleus (PSTN) has recently emerged as a novel interoceptive center in the central nervous system, yet its role in coordinating cardiovascular homeostasis and locomotor behavior remains poorly understood. Here, we demonstrate that PSTN\n                    <jats:italic>\n                      <jats:sup>Vglut2<\/jats:sup>\n                    <\/jats:italic>\n                    neurons serve as a novel baroreflex center, exhibiting heightened activity during acute hypertension. Through their glutamatergic monosynaptic descending projections to the nucleus of the solitary tract (NTS), these neurons mediate parasympathetic output to regulate cardiovascular homeostasis while coordinately modulating locomotor activity. Chemogenetic activation of NTS\u2010projecting PSTN\n                    <jats:italic>\n                      <jats:sup>Vglut2<\/jats:sup>\n                    <\/jats:italic>\n                    neurons rapidly reduces heart rate, attenuates hypertensive responses, and accelerates blood pressure recovery. Conversely, their inhibition exacerbates blood pressure elevations, delays recovery to baseline, and impairs locomotor performance. Correlation analyses reveal a significant negative relationship between blood pressure fluctuations and locomotor metrics, such as total running distance and high\u2010speed locomotion duration, underscoring the interdependence of cardiovascular stability and motor function. These findings position the PSTN as a critical central command hub, offering novel insights into the neural circuits governing cardiovascular homeostasis and locomotion, with potential implications for targeted neuromodulatory interventions in hypertension.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417353","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:45:42Z","timestamp":1753699542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice"],"prefix":"10.1002","volume":"12","author":[{"given":"Ming\u2010Xuan","family":"Lu","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education) &amp; Affiliated Mental Health Center (ECNU) &amp; School of Psychology and Cognitive Science &amp; East China Normal University  Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u2010Ni","family":"Zou","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Cardiology &amp; Shanghai Chest Hospital &amp; School of Medicine &amp; Shanghai Jiao Tong University  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education) &amp; Affiliated Mental Health Center (ECNU) &amp; School of Psychology and Cognitive Science &amp; East China Normal University  Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-6771","authenticated-orcid":false,"given":"Wei\u2010Cai","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology and Department of Prosthodontics &amp; Stomatological Hospital and Dental School &amp; Tongji University  3663 Zhongshan North Road Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac061"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.10.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk8511"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05748-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.08.050"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00027.2016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322791"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000605"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9179-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00729-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04890-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.315895"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2022.108425"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05139-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00889.2005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2023.108589"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.08.027"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00014.2021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04760-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273164"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad115"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15097"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-082321-025137"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305581"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110598"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.06.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-1028-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108906"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1379-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004914117"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00437.2007"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.08.010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22914-6"},{"key":"e_1_2_8_36_1","first-page":"450","volume":"11","author":"Whitman M.","year":"2021","journal-title":"Am. 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