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Moreover, vinyl sulfoxonium ylide can be converted into a broad range of high\u2010value compounds, thus they have been widely employed in organic synthesis. However, the synthesis of alkene\u2010substituted amide\u2010sulfoxonium ylides via intermolecular hydrocarbonation of alkynes remains underexplored. This study describes the development of a high\u2010throughput approach to provide diverse functionalized\n                    <jats:italic>E<\/jats:italic>\n                    \u2010alkene substituted (hetero)amide\u2010sulfoxonium ylides. The reaction occurs under mild metal\u2010free conditions, employing amide\u2010sulfoxonium ylides as highly effective nucleophiles, which participate in Michael addition reactions with various substituted alkynes, such as esters, thioesters, ketones, amides, and sulfones. This low\u2010cost, operationally simple approach has a broad substrate scope, high functional group compatibility, and excellent regio\u2010 and stereoselectivity, making it suitable for the transformation of structurally complex molecules. Furthermore, the obtained stabilized sulfoxonium ylide products are directly useful for the synthesis of diverse valuable 1,5\u2010dicarbonyl and thiabenzene 1\u2010oxide compounds.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417362","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:04:33Z","timestamp":1743743073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Catalyst\u2010Free Direct Hydrocarbonation of Terminal Alkynes Toward\n                    <i>E<\/i>\n                    \u2010Alkene Substituted Stabilized Sulfoxonium Ylides"],"prefix":"10.1002","volume":"12","author":[{"given":"Haiting","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou Laboratory Guangzhou Medical University  Guangzhou 511436 China"},{"name":"Bioland Laboratory  Guangzhou 510005 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