{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:24:06Z","timestamp":1786976646379,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Abstract<\/jats:title>\n \n Sonodynamic therapy (SDT) has good feasibility to deeply seated infections, but SDT alone is insufficient being highly effective against multidrug\u2010resistant (MDR) bacteria. SDT combined with triphenylphosphanium bromide (P\n +<\/jats:sup>\n Ph\n 3<\/jats:sub>\n Br\n \u2212<\/jats:sup>\n ) is expected to solve this problem. This work develops a pseudo\u2010conjugated polymer P\n FCPS\u2010P<\/jats:sup>\n containing cationic P\n +<\/jats:sup>\n Ph\n 3<\/jats:sub>\n Br\n \u2212<\/jats:sup>\n \u2010modified sonosensitizer FCPS (FCPS\u2010P) and ROS\u2010sensitive thioketal bonds. P\n FCPS\u2010P<\/jats:sup>\n is assembled with DSPE\u2010mPEG\n 2000<\/jats:sub>\n to generate nanoparticle NP\n FCPS\u2010P<\/jats:sup>\n . FCPS has SDT effect and generates ROS under ultrasound (US) stimulation. ROS triggers the degradation of NP\n FCPS\u2010P<\/jats:sup>\n and release of FCPS\u2010P, endowing highly favored biosafety. FCPS\u2010P targets to bacterial surface through electrostatic interaction and achieves bacterial killing under a synergistic action of SDT and P\n +<\/jats:sup>\n Ph\n 3<\/jats:sub>\n Br\n \u2212<\/jats:sup>\n . In vitro, NP\n FCPS\u2010P<\/jats:sup>\n +US gives >90% inhibition rates against MDR ESKAPE pathogens, moreover, it causes bacterial metabolic disorders including inhibited nucleic acid synthesis, disordered energy metabolism, excessive oxidative stress, and suppressed biofilm formation and virulence. In mice, NP\n FCPS\u2010P<\/jats:sup>\n +US exhibits a 99.3% bactericidal rate in\n Pseudomonas aeruginosa<\/jats:italic>\n \u2010induced sublethal pneumonia and renders a 90% animal survival rate in lethal pneumonia, and additionally immunological staining and transcriptomics analyses reveal that NP\n FCPS\u2010P<\/jats:sup>\n +US induces inhibited inflammatory response and accelerated lung injury repair. Taken together, NP\n FCPS\u2010P<\/jats:sup>\n +US is a promising antibiotics\u2010alternative strategy for treating deeply seated bacterial infections.\n <\/jats:p>","DOI":"10.1002\/advs.202417469","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T10:53:26Z","timestamp":1743591206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide\u2010modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia"],"prefix":"10.1002","volume":"12","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences Beijing 100071 China"},{"name":"Northern Medical Branch of PLA General Hospital Beijing 100094 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