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Here, a novel extracorporeal device is reported that can eliminate various intact bacteria from whole blood, employing microfluidic bacterial margination and engineered cell\u2010depleted thrombus (CDT) presenting bacterial adhesin receptors. The critical strain rate of red blood cells (RBCs) (0.83 \u00d7 10\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) and the flow path height within about 300\u00a0\u00b5m required for RBC axial migration in the flows are found. The subsequent RBC\u2010bacteria collisions induced bacterial margination, facilitating their effective capture on the CDT surface on the channel wall. Fibrinogen and fibronectin in CDT are found to primarily contribute to capturing various bacteria. The extracorporeal CDT filters (eCDTF), which integrate all these principles, demonstrate significant depletion of major antibiotic\u2010resistant and human fecal bacteria from the whole blood in vitro. Remarkable reductions in bacterial load and inflammatory markers in the rats lethally infected with methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    are further confirmed, resulting in the restoration from bacteremia following extracorporeal treatment. The demonstration may propose a new design principle for hemoadsorption devices and elucidate the limited success of conventional treatments.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417498","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T07:05:26Z","timestamp":1745651126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Red Blood Cell\u2010Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell\u2010Depleted Thrombi, Restoring Severe Bacteremia in Rats"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-9692","authenticated-orcid":false,"given":"Bong Hwan","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  UNIST gil 50 Ulsan 44919 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-1400","authenticated-orcid":false,"given":"Su Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  UNIST gil 50 Ulsan 44919 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  UNIST gil 50 Ulsan 44919 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-9940","authenticated-orcid":false,"given":"Sung Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  UNIST gil 50 Ulsan 44919 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-3209","authenticated-orcid":false,"given":"Joo H.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  UNIST gil 50 Ulsan 44919 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-023-02068-x"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1556\/1886.2015.00021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16388"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.05.020"},{"key":"e_1_2_9_5_1","first-page":"23","author":"Garc\u00eda\u2010Rodr\u00edguez J. 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