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Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE\u2010associated infertility (OEI). A single\u2010cell atlas of pre\u2010ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron\u2010induced senescence phenotypes. Spatial transcriptomics using Stereo\u2010seq in iron\u2010overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload\u2010related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI.<\/jats:p>","DOI":"10.1002\/advs.202417528","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T09:58:40Z","timestamp":1753178320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrative Single\u2010Cell Analysis Reveals Iron Overload\u2010Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis\u2010Associated Infertility"],"prefix":"10.1002","volume":"12","author":[{"given":"Yangshuo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University  Shanghai 200433 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