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While hydrophilic hemostatic materials are effective, they may cause excessive blood loss and difficulty removing from the wound. Conversely, hydrophobic hemostatic materials avoid these issues\u00a0but may hinder blood concentration and the release of procoagulant factors due to their water\u2010repellent nature. This study investigates the hemostatic properties and underlying mechanism of puffball (<jats:italic>Bovistella<\/jats:italic> sp.) spores, a traditional hemostatic material. The unique hollow ball\u2010rod morphology and strong water affinity of puffball spores enable efficient water removal, leading to improved blood clotting without the drawbacks typically associated with hydrophilic hemostatic materials. Further analysis reveals that the nano\u2010protrusions on the spore surface create a textured hydrophobic surface due to the pinning effect, which prevents adhesion to the wound after clotting. Overall, puffball spores exhibit hemostatic efficacy comparable to the commercial agent QuikClot, with enhanced safety and reduced side effects. Their characteristic morphology, physicochemical properties, and chemical compositions offer inspiration for advancing hemostatic materials and addressing current challenges in wound healing. Additionally, this work provides new perspectives for insight into the pharmacological substance basis of traditional medicine, expanding beyond the conventional component\u2010focused mentality to a material\u2010based insight.<\/jats:p>","DOI":"10.1002\/advs.202417566","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T18:26:24Z","timestamp":1741458384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Morphology Effect of Puffball Spores on Hemostasis: A Promising Solution for Hemostatic Challenges"],"prefix":"10.1002","volume":"12","author":[{"given":"Xuechang","family":"Pei","sequence":"first","affiliation":[{"name":"Institute of Traditional Chinese Medicine &amp; Natural Products College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability Assessment International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou Guangdong 510632 P. 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