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As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, the biological behaviors of tumor\u2010associated mast cells (TAMCs) remain unclear. Herein, an excessive infiltration of TAMCs in PDAC is demonstrated, which apparently associated with poor survival in PDAC patients. PDAC cells are found to recruit CXCR2\n                    <jats:sup>+<\/jats:sup>\n                    MCs into TME, and then inhibited MCs ferroptosis, and maintained their proliferation. Concomitantly, the tumor\u2010derived exosome miR\u2010188\u20105p activated the PTEN\/AKT\/GSK3\u03b2 signaling, further stabilized transcriptional factor ERG by inhibiting its ubiquitin degradation, and finally enhanced the transcription of\n                    <jats:italic>cxcl10<\/jats:italic>\n                    within TAMCs. In reverse, TAMCs\u2010derived CXCL10 reversely promoted tumor epithelial\u2010mesenchymal transition and induced immunosuppressive tumor microenvironment by recruiting CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    Tregs. Sodium cromoglycate (SCG) is a membrane stabilizer for MCs and confirmed as an effective and widely used agent to block TAMCs\u2010derived CXCL10 and further sensitize the therapeutic efficacy of anti\u2010PD\u20101 antibody plus gemcitabine for PDAC. These findings illuminate a critical and innovative crosstalk between TAMCs and PDAC cells that promote PDAC progression, and SCG sensitizes PDAC to the current immuno\u2010chemotherapy, which reveals its potential to be a valuable adjuvant for PDAC patients.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417724","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T13:50:36Z","timestamp":1739886636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Crosstalk with CXCL10\u2010Rich Tumor\u2010Associated Mast Cells Fuels Pancreatic Cancer Progression and Immune Escape"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-4301","authenticated-orcid":false,"given":"Hanlin","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Pancreatic Surgery Zhongshan Hospital Fudan University  Shanghai 200032 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