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These injuries need immediate attention in the combat zone, but treatment options are limited as life\u2010saving measures are often prioritized. To address this critical gap, we have developed OcuPair\n                    <jats:sup>TM<\/jats:sup>\n                    , a two\u2010component hydrogel system that consists of i) an injectable viscoelastic filler that stabilizes the ocular cavity and prevents hypotony. ii) An in situ photo\u2010curable adhesive hydrogel comprising of methacrylated, hydroxyl PAMAM dendrimer and hyaluronic acid engineered to form a transparent, flexible, and robust bandage within 90\u00a0seconds, adhering to the corneal surface and ensuring a water\u2010tight seal securing full\u2010thickness corneal wounds. Ex\u00a0vivo studies demonstrated that the adhesive hydrogel is mechanically robust and withstands intraocular pressures beyond physiological range. In a rabbit corneal injury model, OcuPair\n                    <jats:sup>TM<\/jats:sup>\n                    \u00a0effectively sealed complex full\u2010thickness wounds and preserved the eye with favorable clinical outcomes for 5 days with no toxicity over 30 days. In this study, we have validated the pilot scale synthesis, formulation optimization, GMP scale\u2010up, and IDE\u2010enabling GLP toxicity, essential for clinical translation as a battlefield\u2010ready solution.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417731","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T05:07:49Z","timestamp":1743311269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["OcuPair, a Novel Photo\u2010crosslinkable PAMAM Dendrimer\u2010Hyaluronic Acid Hydrogel Bandage\/Bioadhesive for Corneal Injuries and Temporary Corneal Repair"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1402-7112","authenticated-orcid":false,"given":"Siva P.","family":"Kambhampati","sequence":"first","affiliation":[{"name":"Center for Nanomedicine Wilmer Eye Institute Department of Ophthalmology Johns Hopkins University School of Medicine  Baltimore MD USA"},{"name":"Ashvattha Therapeutics, Inc.  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