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To overcome these problems, a new kind of selenium\u2010doped Ag\/Ag\n                    <jats:sub>2<\/jats:sub>\n                    S Janus nanoparticles (Ag\/Ag\n                    <jats:sub>2<\/jats:sub>\n                    Se\n                    <jats:sub>x<\/jats:sub>\n                    S\n                    <jats:sub>y<\/jats:sub>\n                    JNPs) is presented as radio\u2010responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X\u2010ray absorption and energy storage properties. Upon X\u2010ray irradiation, the Ag\/Ag\n                    <jats:sub>2<\/jats:sub>\n                    Se\n                    <jats:sub>x<\/jats:sub>\n                    S\n                    <jats:sub>y<\/jats:sub>\n                    JNPs interact with overexpressed hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) in tumor cells, generating highly toxic hydroxyl radicals (\u00b7OH), which effectively induce tumor cell apoptosis. Additionally, Selenium incorporation improves electron\u2013hole pair separation efficiency and enhances the photocurrent response, promoting increased electron transfer and \u00b7OH generation, thus amplifying reactive oxygen species (ROS) production and enhancing radiosensitization. Furthermore, the fluorescence \u201cOFF\u2010ON\u201d mechanism, triggered by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced etching of silver allows real\u2010time monitoring of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    levels via the second near\u2010infrared window (NIR\u2010II) fluorescence (FL) imaging \u201cTurn On\u201d, which delineates tumor boundaries for precise RT and reduce side effects to normal tissue. This dual\u2010functional platform not only enables real\u2010time tracking but also enhances therapeutic outcomes, offering a promising approach to precision cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202417828","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:05:31Z","timestamp":1744891531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Radio\u2010Activated Selenium\u2010Doped Janus Ag\/Ag\n                    <sub>2<\/sub>\n                    Se\n                    <sub>x<\/sub>\n                    S\n                    <sub>y<\/sub>\n                    Nanoparticles for Precise Cancer NIR\u2010II Fluorescence Imaging and Radiosensitization Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Kang","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology  Beijing 100029 P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxun","family":"Zou","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ecology\u2010Toxicological Effects &amp; Control for Emerging Contaminants Key Laboratory of Ecological Environment and Information Atlas College of Environmental and Biological Engineering Putian University  Putian 351100 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunsheng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering College of Chemistry College of Chemical Engineering Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Mu","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine Peking University Shenzhen Hospital  Shenzhen 518036 P. R. 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