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However, disease\u2010specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single\u2010cell RNA sequencing (scRNA\u2010seq) are performed in patients with BU and healthy controls (HC). scRNA\u2010seq data of experimental autoimmune uveitis (EAU) mice are also incorporated. The data showed an altered metabolic profile, characterized by upregulated glycolysis in BU. MYC is predicted to be a hub molecule regulating glycolysis and T cell response. Notably, it is discovered that the expression level of MYC is higher in BU compare to HC and may reflect the treatment response of BU disease. Correspondingly, the scRNA\u2010seq data of EAU mice also reveal higher glycolysis levels and MYC expression. Further studies reveal that inhibition of MYC repressed glycolysis and exerted therapeutic effects similar to those of glycolysis inhibitors, including amelioration of EAU and repression of the abnormal response of effector T cells (T helper [Th]\u20101 and Th17 cells). Mechanically, inhibiting MYC disrupts the glycolysis\u2010PI3K signaling circuit to curb the effector T cell response in uveitis. Collectively, the study indicated that MYC promoted glycolysis to fuel abnormal T\u2010cell responses, thus therapeutically targeting MYC would provide an attractive approach for treating BU.<\/jats:p>","DOI":"10.1002\/advs.202417843","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T10:25:12Z","timestamp":1751279112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Beh\u00e7et's Uveitis"],"prefix":"10.1002","volume":"12","author":[{"given":"He","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"State Key Laboratory of Eye Health Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  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