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Although both conditions are linked to the aging process, the relationship among cellular senescence, diabetes, and atherosclerosis remains inadequately understood. This study presents evidence that elevated glucose levels expedite the progression of atherosclerosis by promoting macrophage senescence. Increased glucose levels are shown to induce senescence in macrophages, which enhances the uptake of oxidized low\u2010density lipoprotein (ox\u2010LDL) and facilitates the formation of foam cells. This mechanism is driven by lactate production via glycolysis, which activates the lactate receptor GPR132, thereby promoting macrophage senescence. The activation of GPR132 is implicated in mediating senescence and lipid uptake through Src phosphorylation. The deletion of GPR132 markedly reduces macrophage senescence and atherosclerosis in mouse models. Furthermore, saracatinib, a specific Src inhibitor, has been demonstrated to effectively alleviate diabetic atherosclerosis in experimental settings. In clinical samples, elevated plasma lactate levels and the activation of the GPR132\u2010Src pathway in peripheral blood mononuclear cells (PBMCs) are positively associated with coronary stenosis. These findings propose a potential mechanism through which diabetes accelerates atherosclerosis via the lactate\u2010GPR132\u2010Src pathway, underscoring macrophage senescence as a pivotal target in the context of diabetic atherosclerosis.<\/jats:p>","DOI":"10.1002\/advs.202500141","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:08:22Z","timestamp":1749726502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lactate\u2010Activated GPR132\u2010Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaofeng","family":"Ge","sequence":"first","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine Fujian Branch of National Clinical Research Center for Cardiovascular Diseases Xiamen University  Xiamen 361016 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