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Activation of nociceptors in acute inflammatory pain (AIP) significantly reduced sleep by 45\u201350% in the first 6 h, with reduced sleep spindle density for 1\u20133 h post\u2010AIP. Additionally, an \u201coptogenetic pain (Opto\u2010Pain)\u201d model is implemented to produce acute peripheral pain\u2010induced awakenings that reduced sleep comparable to AIP. Both pain models are used to test the role of wake\u2010promoting neurons in the parabrachial nucleus that express Calcitonin Gene\u2010Related Peptide (PBel<jats:sup>CGRP<\/jats:sup>) in relaying nociceptive stimulus from the dorsal horn as part of the spine\u2010ponto\u2010amygdaloid tract. Blocking PBel<jats:sup>CGRP<\/jats:sup> neurons with genetic ablation or optogenetic inhibition attenuated sleep loss. To dissect the PBel<jats:sup>CGRP<\/jats:sup> pathways, the terminals are then optogenetically silenced post\u2010AIP and found the reversal of sleep disturbances in the following descending order of effectiveness: substantia innominata of the basal forebrain (SI\u2010BF) &gt; central nucleus of the amygdala (CeA) &gt; bed nucleus of the stria terminalis (BNST) &gt; the lateral hypothalamus (LH). In SI\u2010BF and CeA, a similar reversal of AIP\u2010induced sleep loss occurred with pharmacological blocking of either CGRP or NMDA receptors. The results are relevant to emerging pain therapies aiming to attenuate sleep disturbances.<\/jats:p>","DOI":"10.1002\/advs.202500325","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T12:17:58Z","timestamp":1752409078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calcitonin Gene\u2010Related Peptide (CGRP)\u2010Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain\u2010Induced Sleep Disturbances"],"prefix":"10.1002","volume":"12","author":[{"given":"Nicole","family":"Lynch","sequence":"first","affiliation":[{"name":"Department of Neurology Division of Sleep Medicine and Program in Neuroscience Beth Israel Deaconess Medical Center and Harvard Medical School  Boston MA 02215 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-426X","authenticated-orcid":false,"given":"Roberto","family":"De 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