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To address this clinical challenge, a biomimetic microneedle (MN) suction cup is designed inspired by the tarsal claw of Drosophila. The suction cup component is crafted from polyvinyl alcohol (PVA) hydrogel, while the MN section, embedded within the suction cup, comprises a thermoresponsive and antibacterial composite hydrogel infused with the drug S\u2010nitrosoglutathione (GSNO). This innovative design not only ensures strong adhesion to moist surfaces but also provides substantial antibacterial and anti\u2010inflammatory effects, controlled drug release, active promotion of concentric wound contraction, and enhanced vasodilation, thereby facilitating rapid and comprehensive healing of BIS. 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