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Herein, copper tungstate (CuWO\u2084, CWO) nanoparticles with ultrasmall bandgap (1.71 eV) is developed as both piezoelectric\u2010catalysis agents and copper nanocarriers for synergistic sono\u2010enhanced cuproptosis. Owing to the unique bandgap microstructure, exposure to ultrasound (US) significantly increase the generation of reactive oxygen species (ROS) and the release of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    from CWO. Additionally, \u224860% of glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH) are consumed in situ, leading to oxidative stress, ferroptosis, and cuproptosis in cancer cells. This cascading approach induces substantial mitochondrial dysfunction and the release of damage\u2010associated molecular patterns (DAMPs), which promotes immunogenic cell death (ICD) and augments antitumor immunity. Both in vitro and in vivo studies have shown that this sono\u2010enhanced cuproptosis\u2010based therapy could effectively suppress tumor growth. Overall, this study investigates a novel Structure\u2010Function therapeutic approach that combines piezoelectric catalysis, ferroptosis, cuproptosis, and cascade activation of immune regulation, opening up new possibilities for addressing the challenges associated with conventional cuproptosis therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202500576","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T10:40:10Z","timestamp":1747824010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High\u2010Efficiency Carriers\u2019 Separation Strategy Based Ultrasmall\u2010Bandgap CuWO\n                    <sub>4<\/sub>\n                    Sono\u2010Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Lichao","family":"Zhu","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non\u2010coding RNA Institute for Frontier Medical Technology School of Chemistry and Chemical Engineering Shanghai University of Engineering Science  Shanghai 201620 P. 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